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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Airo, Adriana M
- 1Arendt, Christopher William.
- 1Awadh, Abdullah
- 1Azaizeh, Bara'ah
- 1Bacik, John-Paul
- 8Evans, David (Medical Microbiology and Immunology)
- 6Foley, Edan (Medical Microbiology and Immunology)
- 5Barry, Michele (Medical Microbiology and Immunology)
- 5Ingham, Robert (Medical Microbiology and Immunology)
- 5Ostergaard, Hanne (Medical Microbiology and Immunology)
- 3Baldwin, Troy (Medical Microbiology and Immunology)
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Fall 2023
The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial...
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Intracellular expression of Fas Ligand and Granzyme B by tumor infiltrating or in vitro activated CD8+ T cell populations
DownloadSpring 2019
CD8+ T cells can recognize infected or cancerous cells and eliminate them by exocytosing cytolytic molecules or presenting death ligands on their surface, both of which can initiate apoptosis in target cells. Granzyme B (GzmB) and Fas Ligand (FasL) are two of the effector proteins that CD8+ T...
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Investigating and characterizing the direct binding interactions between chemotherapeutic cisplatin and pattern recognition receptor, Toll-like Receptor 4
DownloadFall 2022
Cisplatin is one of the most effective chemotherapeutic agents available. Unfortunately, adverse drug reactions - cisplatin-induced toxicities - often limit the use of cisplatin. These toxicities develop in at least half of those treated, are diverse, and are especially problematic for pediatric...
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Investigating barriers to vaccinia virus recombination using combinations of light and electron microscopy
DownloadSpring 2020
While DNA viruses typically replicate in the nucleus of the host cell, poxvirus replication occurs exclusively within cytoplasmic structures known as viral factories. Viral factories are the sites of various processes of the vaccinia virus (VACV) life cycle including replication, morphogenesis...
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Spring 2013
The activation of caspases is an important step not only in apoptosis induction, but in cellular processes such as proliferation, differentiation, and the immune response. Here, we show that the AP-1 family transcription factor JunB is cleaved and dephosphorylated in a caspase-dependent manner in...
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Investigating the differential effects of LILRB1 natural variants on interaction with MHC-I and UL18
DownloadFall 2022
The Leukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed throughout human immune cells of lymphoid and myeloid origins. It is also associated with viral infection, autoimmune diseases and cancer. LILRB1 regulates immune responses through broad interaction with major...
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Investigating the functions and interactions of Salmonella effector SspH2 with intracellular innate immune receptors
DownloadFall 2021
As part of its pathogenesis, Salmonella enterica serovar typhimurium delivers effector proteins into host cells. One such effector is SspH2, a member of the novel E3 ubiquitin ligase (NEL) family, which has been reported to interact with, and enhance, NOD1 pro-inflammatory signaling. It is still...
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Investigating the functions of the c-Jun and JunB transcription factors in classical Hodgkin Lymphoma
DownloadFall 2016
Classical Hodgkin lymphoma (cHL) is characterized by the presence of abnormal mononuclear Hodgkin and multinuclear Reed-Sternberg (HRS) cells, which are thought to be derived from clonally expanded germinal center B cells. The tumour cells have been demonstrated to have various signalling...
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Fall 2019
T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...
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Investigating the role of the base mismatches within the hairpin ends of vaccinia virus genome in viral life cycle
DownloadSpring 2023
The genome of poxviruses consists of a double-stranded DNA that is flanked by two AT-rich hairpin ends encoding mismatched nucleotides. These mismatched structures are composed of incompletely base paired regions forming extra-helical loops. Though the functionality of these mismatches has not...