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- 1Aktary, Zackie M
- 1Anderson-Baron, Matthew N
- 1Armstrong, Heather K
- 1Baier, Alicia
- 1Bodman, James A. R.
- 1Brown, Trevor Wayne.
ADP-ribosylation factors (Arfs) play a central role in the regulation of vesicular trafficking through the Golgi. Arfs are activated on cis-Golgi membranes exclusively by the guanine nucleotide exchange factor (GEF) Golgi-specific BFA resistance factor 1 (GBF1), upon recruitment from cytosol....
A Role for Pom121 in Linking the Nuclear Pore Complex Membrane Scaffold to the ￼Pore Membrane DomainDownload
A key step in the evolutionary progression from prokaryote to eukaryote was development of the endomembrane system, including encapsulation of genetic material by the impermeable nuclear envelope (NE). Trafficking of macromolecules between cytoplasmic and nuclear compartments required the...
A comprehensive assessment of peroxisome biology: ER-dependent peroxisome proliferation control, evolution of organelle inheritance in yeast and a Drosophila model system of Zellweger syndromeDownload
The modern eukaryotic cell is a meshwork of encapsulating membranes that compartmentalize many distinct biochemical processes. It is complex. This complexity facilitates the many unique and diverse processes that aid the eukaryote in its growth, division and adaptation to its environment. A...
A novel group of zebrafish Class II ADP-ribosylation factors and their potential role in photoreceptor developmentDownload
In this study we identified an unknown set of Class II Arf isoforms in zebrafish. Bioinformatics analyses grouped these paralogues into three distinct clades. Using antisense morpholino gene knockdown, we tested the effect of loss of each zebrafish Class II Arf on early development and...
A role for the nuclear pore complex protein Nup170p in defining chromatin structure and regulating gene expressionDownload
The spatial organization of chromosomal loci within the nucleus can have a significant influence on transcriptional activity. Transcriptionally active genes are generally positioned within the nuclear interior. By contrast, the positioning of genes at the nuclear periphery is often correlated...
A role for the nuclear transport machinery in supporting positive-strand RNA virus infection and in regulating innate immune responsesDownload
In eukaryotic cells, the genetic material is encapsulated in a double lipid membrane layer to form the nuclear compartment. This double membrane layer, termed the nuclear envelope, is fenestrated by pores, which are occupied by proteinaceous gateway structures termed nuclear pore complexes...
An ancestral role in de novo peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolyticaDownload
This thesis is on peroxisome evolution and reports my findings with regard to two major aspects of this process. First, I investigated the evolution of a peroxisomal protein family for which large expansions had been noted in diverse eukaryotes from a comparative genomic perspective and combined...
RNA interference (RNAi) is a phenomenon in which small RNAs induce an efficient, sequence-specific silencing of gene expression at transcriptional (TGS) and post-transcriptional (PTGS) levels. In the fission yeast Schizosaccharomyces pombe (S. pombe), the basic roles of Argonaute protein (Ago1),...