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Skip to Search Results- 9Michelakis, Evangelos (Medicine)
- 2Moore, Ronald (Surgery)
- 2Nagendran, Jayan (Surgery)
- 1Dyck, Jason (Pharmacology)
- 1Freed, Darren (Surgery)
- 1Khoo, Nee Scze (Pediatrics)
- 13D Echocardiography
- 1Apoptosis
- 1Cancer
- 1Cancer Metabolic Modulators
- 1Cancer, metabolism, epigenetics, renal cell carcinoma
- 1Cell death
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Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
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A Novel Association Between Primary Biliary Cholangitis and Idiopathic Pulmonary Arterial Hypertension
DownloadFall 2020
Background and Hypothesis Idiopathic Pulmonary Arterial Hypertension (IPAH) and Primary Biliary Cholangitis (PBC) are both rare diseases that are progressive and may be fatal when left untreated. Furthermore, mitochondrial dynamics are fundamental to the pathogenesis of both conditions. An...
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A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in Cancer
DownloadFall 2021
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...
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Development of a Novel Piglet Model to Simulate the Physiology of a Child with Hypoplastic Left Heart Syndrome during the First Interstage for Investigating Changes in Tricuspid Valve as it Adapts to a High-pressure and High-volume Stress Environment
DownloadSpring 2020
INTRODUCTION: Tricuspid valve (TV) failure develops in 25-35% of children with hypoplastic left heart syndrome (HLHS) and is a risk factor for morbidity and mortality. The mechanisms underlying TV failure in HLHS are not well understood. There is no effective medical therapy and current surgical...
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Fall 2009
The right ventricle (RV) of the heart is clearly an extremely important component of cardiovascular function and physiology. The RV is affected in many cardiovascular disease processes, including pulmonary arterial hypertension (PAH), congenital heart disease, and left ventricular failure. In...
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Spring 2012
Maximizing the possibility of effectively treating cancer requires timely assessment of its aggressiveness and susceptibility to drug intervention. During cancer surgery, the “fast biopsy” is a commonly employed technique to assess a tumor’s invasiveness and guide surgery. Unfortunately, it is...
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Spring 2018
Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...
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Spring 2018
Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...
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Spring 2013
Mitochondria generate reactive oxygen species (mROS) and metabolic substrates like alpha-ketogluterate (αKG), in proportion to oxygen, which target extra-mitochondrial effectors to coordinate a cellular response. For example, acute hypoxia decreases mROS, resulting in pulmonary artery smooth...