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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Molecular and cellular roles of the N-end rule pathway in apoptotic cell death in mammalian-derived cell lines
DownloadFall 2017
Cellular stresses and signaling that lead to the initiation of apoptotic pathways often result in the activation of proteases such as caspases which in turn culminate in the generation of proteolytically activated protein fragments with new or altered roles. Recent work has revealed that the...
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Molecular and Epigenetic Insights into RASSF1A Regulated Pathways in Inflammatory Bowel Disease
DownloadFall 2018
Inflammatory Bowel Disease (IBD) is an idiopathic non-curable disease characterized by pain, chronic diarrhea, rectal bleeding with weight loss and erosion of the colon in severe cases. In many cases, IBD is a chronic relapsing inflammatory disorder of the gastrointestinal tract that usually...
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Fall 2017
The information contained in our genome is essential for the proper functioning of different physiological processes in cells that are required for our growth and survival, making the maintenance of genome integrity a task of utmost priority. Our cells have evolved a highly elaborate, complex and...
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Molecular Basis of Escherichia coli L/F transferase: Catalytic Mechanism and Substrate Specificities
DownloadFall 2014
The Escherichia coli leucyl/phenylalanyl-tRNA protein transferase (L/F transferase) catalyzes the tRNA-dependent post-translational addition of amino acids onto the N-terminus of a protein polypeptide substrate. The enzymatic N-terminal addition of an amino acid to a protein has been identified...
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Fall 2011
Topoisomerase II-beta binding protein 1 (TopBP1) is a critical regulatory protein that integrates diverse signals in the DNA damage response. In response to DNA replication stress, TopBP1 participates in a series of protein interactions to collectively activate the key Ser/Thr kinase, Ataxia...
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Spring 2013
K63-linked polyubiquitin is synthesized by the E2 Ubc13, and plays non-degradative roles in immunity and the DNA damage response, yet a full molecular understanding of its synthesis and subsequent recognition remains incomplete. Although previously considered a slow enzyme, we demonstrate that...
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Fall 2018
Sudden unexplained death (SUD) is a term used when comprehensive medical examination and autopsy fail to find a conclusive cause of sudden death. In cases of SUD, post-mortem molecular and genetic evaluation methods have helped identify ion channel abnormalities leading to arrhythmias as cause....