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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Spring 2022
Eukaryotes feature a split gene structure in which pre-mRNAs are spliced into mature RNAs prior to the translation of proteins. The splicing process is catalyzed by a dynamic multi-subunit molecular machine known as the spliceosome that assembles in a stepwise fashion. An early complex formed in...
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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Investigation of the BRCT repeats in human hereditary breast cancer and DNA damage response
DownloadFall 2009
The C-terminal region of breast cancer susceptibility gene 1 (BRCA1) contains a pair of tandem BRCT repeats that are critical for the tumour suppressor function of BRCA1. BRCT repeats are present in a large of number of proteins that are implicated in the cellular response to DNA damage. A subset...
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Spring 2018
The BRCT domain family is a group of proteins that is primarily involved in the regulation of DNA replication, cell cycle checkpoint activation, DNA damage repair, and many other DNA damage responses (DDR). Mutations in BRCT proteins often result in genomic instability, one of the leading sources...