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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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The effects of carotid chemoreceptor inhibition on exercise tolerance in health and chronic heart failure
DownloadFall 2018
Background and Rationale: Chronic heart failure (CHF) is a condition where heart function is insufficient to meet metabolic demand and is caused by anatomical or physiological abnormalities of the heart. In 2009, one in nine deaths included heart failure as a contributing cause, and the five-year...