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Changes in Retinal Mitochondrial Function in Ocular Diseases and a Potential Treatment Using Near-Infrared Light
DownloadFall 2018
Mitochondria are both prominent target and source of reactive oxygen species (ROS). Their role in a wide range of diseases has been gaining a substantial amount of interest, including a number of high-profile ocular diseases. In the present thesis, we investigated the mitochondrial functional...
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Spring 2019
Dramatic maturational changes occur in heart energy metabolism in the fetal to newborn transition, most predominantly marked by a decrease in glycolysis and an increase in fatty acid oxidation which then becomes the major energy providing substrate for the heart after birth. However, in the...
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Cardioprotective Effects of Soluble Epoxide Hydrolase Inhibition Following Myocardial Infarction
DownloadFall 2020
Ischemic heart disease (IHD) is a significant cause of morbidity and mortality for Canadians. While mortality rates from myocardial infarction (MI) and heart failure (HF) have decreased, IHD remains the number one cause of premature mortality. Both age and sex are important contributors for IHD...
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Cardioprotective effects of n-3 and n-6 PUFA derived epoxylipids against age-related cardiac alterations
DownloadSpring 2021
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals. A steady decline in mitochondrial function is recognized as an important biological consequence found in...
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Specific reduction in complex I of the mitochondrial electron transport system in long-lived seed beetles
DownloadSpring 2023
Background: Mitochondrial dysfunction is a recognized hallmark of aging that is also directly or indirectly connected to practically all the other hallmarks of aging. As a result, mitochondrial dysfunction seems to be an important regulator of lifespan. Many studies provide evidence of lifespan...
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Sex-specific Changes in Neonatal Cardiac Mitochondria in Response to Perinatal Iron Deficiency
DownloadFall 2023
Introduction: Iron deficiency (ID) during gestation has been shown to alter growth and developmental trajectories, consequentially increasing the risk of long-term cardiovascular dysfunction in offspring. The heart becomes energetically dependent on mitochondria soon after birth and disturbances...