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Prevalence and Sex-Specific Risk Factors for Asthma-COPD Overlap among Middle-Aged and Older Canadians
DownloadFall 2021
Background: Asthma and chronic obstructive pulmonary disease (COPD) are major public health concerns and are among the most prevalent chronic respiratory diseases worldwide. However, a subset of patients presents with clinical features of both asthma and COPD, and recently, the term asthma-COPD...
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Fall 2018
Proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor, is activated by exogenous or endogenous serine proteinases. PAR-2 is involved in the pathogenesis of inflammatory diseases including asthma. PAR-2 activation on airway epithelial cells (AECs) results in the release of...
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Fall 2019
Background and Rationale Asthma is a chronic inflammatory disease of the airways characterized by episodic bronchoconstriction and airway hyper-responsiveness resulting in symptoms such as coughing, wheezing, and shortness of breath. Asthma is one of the most common chronic diseases in the...