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Synthesis of the repeating unit of Streptococcus pneumoniae (Sp1) zwitterionic polysaccharide
DownloadFall 2010
According to the traditional paradigm, carbohydrates are considered to be poorly immunogenic, T-cell independent antigens. Pure polysaccharides induce specific IgM responses, with minimal class switch to IgG. However, a series of recent investigations has found that a class of zwitterionic...
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