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Spring 2020
Tabatabaei Dakhili, Seyed Amirhossein
Thousands of transcription factors control the process of gene expression and protein synthesis in the human body. These nuclear proteins are fundamental for healthy organ development, cellular function, immunity and body response to diseases and stress. Mutated, overexpressed, or dysregulated...
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Fall 2017
NPAS3 encodes a transcription factor of the bHLH-PAS family, which has been robustly associated with neurodevelopmental and psychiatric disorders with intellectual disability as a common feature. NPAS3 was initially discovered as a schizophrenia-associated gene in a family with a translocation...
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Specific Activation of the Na+/H+ exchanger gene during neuronal differentiation of embryonal carcinoma cells
Download1995-01-01
Dyck, Jason R. B., Fliegel, Larry
We examined the regulation of the NaGraphic/HGraphic exchanger gene during differentiation of the P19 mouse embryonal carcinoma cells. Treatment of P19 cells with retinoic acid induces the development of neurons, astroglia, and microglia cells. Upon retinoic acid-induced differentiation of P19...
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2002-01-01
Li, Xiuju J., Misik, Angelika J., Rieder, Carmen V., Solaro, R. John, Lowen, Anice, Fliegel, Larry
In this paper we examine the role of thyroid hormone in regulating expression of the Na+/H+ exchanger. Thyroid hormone has been reported to regulate the activity of the Na+/H+ exchanger messenger RNA in some cell types. Treatment of cardiac myocytes with 3,5′,3′-triiodothyronine results in an...