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Skip to Search Results- 2Synthetic lethality
- 1DNA repair
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- 1Polymeric micelles
- 1Polynucleotide kinase phosphatase
- 1Polynucleotide kinase/phosphatase
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Novel Therapeutic Approaches for Cancer Therapy Based on Targeting the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase
DownloadFall 2018
The relentless growth of tumors is triggered by a complex array of molecular changes such as DNA damage, disruption of cell-cycle progression, uncontrolled proliferation and escaping cell death. Various therapies have been developed to treat cancer, many of which kill cancer cells by damaging...
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Synthetic lethal targeting of polynucleotide kinase/phosphatase and its potential role in directed cancer therapies
DownloadFall 2012
Synthetic lethality arises when simultaneous disruption of two non-essential, non-allelic genes in the same cell causes lethality. This phenomenon has been shown to occur between proteins involved in DNA repair and much attention to date has focused on poly(ADP-ribose) polymerase and the BRCA...