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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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