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Skip to Search Results- 13Amino acids
- 6Phenelzine
- 3Monoamine oxidase
- 2Experimental autoimmune encephalomyelitis
- 2Multiple Sclerosis
- 2Neurotransmitters
- 1Afanas'yev, Dmytro
- 1Begam, Rowshon A
- 1Fayadh, Abdullah
- 1Frieser, Emma CG
- 1Kandel, Krishna
- 1Kumpula, David J
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Fall 2017
Amino acids are building blocks for protein synthesis and are essential to every metabolic process. A well-balanced diet is one in which all required amino acids are present in the food that is eaten. Unfortunately, this is not always the case and nutritional supplements can be used to make up...
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Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatment
DownloadFall 2011
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
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Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzine
DownloadFall 2017
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary clinical consequences of MS, the disease is also...
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Conformations of Some Amino Acids in Aqueous Solutions by Vibrational Circular Dichroism Spectroscopy
DownloadFall 2012
Vibrational circular dichroism (VCD) spectroscopy has been utilized to reveal the detailed conformational distributions of the dominant serine species and leucine species in aqueous solutions under three representative pH conditions, together with vibrational absorption (VA) spectroscopy, density...
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Evaluation of the threonine requirement and the bioavailability of threonine in feedstuffs in pregnant sows
DownloadFall 2010
Current recommendations for amino acid intake during pregnancy are for a constant amino acid intake throughout. However, the demand for amino acids changes from maternal tissue growth in early gestation to fetal, conceptus and mammary tissue development in late gestation. The availability of...
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Functional characterization of the L-type Amino acid Transporters (LATs) in Arabidopsis thaliana
DownloadFall 2012
The distribution of amino acids (AAs) in plants is a complex process that involves 67 amino acid transporters (AATs) in Arabidopsis, many of which have yet to be characterized. The L-type Amino acid Transporter (LAT) family, which in Arabidopsis contains five members, remained uncharacterized in...
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Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune Encephalomyelitis
DownloadFall 2017
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...
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Neurochemical and neuroprotective aspects of phenelzine and its active metabolite B-phenylethylidenehydrazine
DownloadFall 2009
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor that also inhibits the activity of GABA-transaminase (GABA-T), causing significant and long-lasting increases in brain GABA levels. Inhibition of MAO prior to PLZ administration has been shown to prevent the GABAergic effects of the drug,...