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Skip to Search Results- 1Banadyga, Logan Elliott
- 1Burles, Kristin A
- 1Campbell, Stephanie D
- 1Irwin, Chad Robert
- 1Lehman, Bettina, J
- 1Magee, Wendy C
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Fall 2012
One of the most notable features of poxviruses is their ability to regulate cellular signaling pathways, including the ubiquitin-proteasome system. Ubiquitin plays a crucial role in the fate of a protein. Typically poly-ubiquitinated proteins are degraded by the 26S proteasome. The Skp1,...
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Fall 2015
Many cellular processes are regulated by the ubiquitin proteasome system (UPS), which utilizes the polypeptide ubiquitin to mark proteins for destruction via the 26S proteasome. Since the UPS plays an important role in cellular homeostasis, many viruses have evolved strategies to regulate the...
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Ectromelia Virus Encodes A Novel Family Of Ankyrin/F-box Proteins That Manipulate The SCF Ubiquitin Ligase And NF-κB Activation
DownloadSpring 2012
Ectromelia virus (ECTV) is the causative agent of lethal mousepox, and is highly related to the human pathogen, variola virus, the causative agent of smallpox. Poxviruses contain large dsDNA genomes that encode numerous open reading frames that manipulate cellular signalling pathways. We used...
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Spring 2012
Apoptosis, an evolutionarily conserved cell death programme, is a potent barrier against virus infection. Central to this process are mitochondria, which harbour cytochrome c and other apoptosis-inducing factors. Once released, these factors activate a caspase cascade that culminates in cell...
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Investigations into Differences between Vaccinia and Myxoma Virus Plaquing Properties Identifies Strategies for Increasing the Oncolytic Efficacy of Myxoma Virus
DownloadFall 2013
Despite both being poxviruses, vaccinia (VACV) and myxoma (MYXV) form very different plaque types. VACV plaques are large and show a central clearing of cells, while MYXV plaques are smaller and result in a clumping of cells. VACV spread is promoted by the formation of an enveloped form of virus...
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Spring 2016
Poxviruses, such as vaccinia virus (VACV) and myxoma virus (MYXV), actively modulate various cellular structures and functions to ensure effective replication and transmission. In the contrary, cells use several restriction mechanisms to mitigate these viruses. This evolutionary relationship is...
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Poxviral manipulation of Bcl-2 proteins: fowlpox virus FPV039 and deerpox virus DPV022 inhibit apoptosis by neutralising Bak and Bax, while Noxa contributes to vaccinia virus-induced apoptosis
DownloadSpring 2011
Poxviruses are renowned for encoding proteins that modulate virtually every aspect of the host immune system. One effective barrier against virus infection is apoptosis, a form of programmed cell death. Apoptosis is controlled at the mitochondria by pro- and anti-apoptotic members of the highly...
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The mechanism of action of cidofovir and (S)-9-(3-hydroxy-2-phosphonomethoxypropyl)adenine against viral polymerases
DownloadFall 2009
The nucleoside phosphonates cidofovir (CDV) and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [(S)-HPMPA] are analogs of dCMP and dAMP, respectively. Collectively these drugs are effective inhibitors of a wide range of DNA viruses, RNA viruses, and retroviruses. Because they are nucleotide...
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Spring 2017
Apoptosis serves as a powerful defense against damaged and unwanted cells. The family of Bcl-2 proteins plays a key role in the regulation of apoptosis at the mitochondria. Members of the Bcl-2 family include pro- and anti-apoptotic members that collectively determine the state of the cell....
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Fall 2010
The significance of poxvirus manipulation of the host ubiquitin proteasome system has become increasingly apparent. Ubiquitin is post-translationally added to target proteins by a highly conserved enzymatic cascade, typically resulting in protein degradation via the 26S proteasome. The highly...