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Skip to Search Results- 9Polymeric micelles
- 2Pharmacokinetics
- 2Targeted delivery
- 120-HETE
- 1ABC triblock copolymer
- 1Active targeting
- 1Al Lawati, Hanan M
- 1Binkhathlan, Ziyad
- 1Garg, Shyam M
- 1Saqr, Asma Ali
- 1Shahin, Mostafa H
- 1Shire, Zahra
- 4Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Afsaneh Lavasanifar
- 1Afsaneh Lavasanifar, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
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Design and synthesis of renewable lipid-based nanocarriers with thermosensitivity for targeted drug delivery applications
DownloadSpring 2024
Numerous drug molecules currently available on the market suffer from short half-life, in vivo instability, poor bioavailability, rapid degradation and inappropriate distribution. While nanocarriers have emerged as a promising solution to address these issues, the primary objective and challenge...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Poly(ethylene oxide)-block-poly(ε-caprolactone) based Micelles for Tumor Targeted Drug and siRNA Delivery
DownloadFall 2015
The use of nanotechnology has made significant advancements in cancer diagnosis and treatment. Polymeric micelles are a relatively new generation of nanocarriers mostly intended for the delivery of hydrophobic drugs. In this thesis, our objective was to develop an optimized polymeric micellar...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Development of traceable Rituximab modified polymeric micelles for active targeting of B-cell Lymphoma
DownloadFall 2017
Abstract B-cell Non-Hodgkin Lymphoma (NHL) accounts for more than 90% of all adult cases of lymphomas and in most cases it is CD20 positive. B-cell NHL is usually treated by combination of conventional chemotherapeutics and the monoclonal antibody against CD20, rituximab. This combination regimen...
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Novel Therapeutic Approaches for Cancer Therapy Based on Targeting the Human DNA Repair Enzyme Polynucleotide Kinase/Phosphatase
DownloadFall 2018
The relentless growth of tumors is triggered by a complex array of molecular changes such as DNA damage, disruption of cell-cycle progression, uncontrolled proliferation and escaping cell death. Various therapies have been developed to treat cancer, many of which kill cancer cells by damaging...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...
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Fall 2016
Arsenic trioxide (ATO), dissolved in water as arsenous acid or inorganic arsenite (AsIII), is an effective chemotherapeutic agent against acute promyelocytic leukemia (APL). It has been investigated as a potential treatment for a variety of solid tumors although with much poorer efficacy than for...