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Skip to Search Results- 1Al-Adra, David P.
- 1Arefanian, Hossein
- 1Ayton, Kelsey L
- 1Clifford, Alexander M
- 1Cole, Dylan M
- 1Deehan, Edward C
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Fall 2016
The increasing anthropogenic pressure on biodiversity in the tropics is resulting in changes to ecosystem structure and increasing species extinction rates (Collen et al. 2013). These issues are heightened in the tropics where 50% of the world’s biodiversity is held in 7% of the world’s...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...
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Fall 2012
In this study, growth of seven hybrid poplar clones and one pure poplar clone was investigated in relation to leaf, shoot, and root physiology under field conditions. Clones included: Walker (24 - P. deltoides x P. xpetrowskyana), Assiniboine (25 - open pollinated Walker cv. Assiniboine),...
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Fall 2019
T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...
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Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
DownloadFall 2016
T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...
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Fall 2011
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
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Respiration, Acid/Base, Ammonia and Ionoregulatory Strategies in the Pacific hagfish (Eptatretus stoutii)
DownloadFall 2016
Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...