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Skip to Search Results- 1 Graham, Sean W
- 1Hagerman, Gordon F
- 1Li, Fay-Wei
- 1Ling, Jennifer YM
- 1Mathews, Sarah
- 1Melkonian, Michael
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Investigating Disease Presentation and Mechanism in RP1L1-Associated Photoreceptor Degeneration
DownloadFall 2021
Photoreceptor disease results in irreparable vision loss and blindness, which has a dramatic impact on quality of life. Retinitis pigmentosa 1-like 1 (RP1L1) is a component of the photoreceptor axoneme, the backbone structure of the photoreceptor’s light-sensing outer segment. Pathogenic variants...
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Fall 2017
Photoreceptors (the light-sensitive cellular mediators of vision in the eye) are divided into two classes: rods, which are sensitive to dim light and responsible for vision in low-light conditions, and cones, which are sensitive to specific wavelengths of light, and are responsible for daytime...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Temporal differences in the recovery of visual function after the selective ablation of blue or UV cone photoreceptors in larval zebrafish
DownloadFall 2016
Retinal degenerative diseases are an irreversible cause of vision loss and blindness caused by the loss of photoreceptors, which are unable to regenerate in the adult human retina. Cone photoreceptor loss is especially debilitating as cones mediate high acuity vision and colour perception....