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Spring 2019
PINK1 (Phosphatase-Tensin homologue (PTEN)-induced putative kinase 1) is a protein kinase heavily involved in mitochondrial health and integrity. It has multiple domains: an N-terminal mitochondrial targeting sequence, a transmembrane domain, and a kinase domain. Some mutations, located...
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Fall 2013
PINK1 (Phosphatase Tensin homologue (PTEN)-Induced Kinase) is a neuroprotective kinase involved in mitochondrial dynamics. It is composed of an N-terminal mitochondrial targeting sequence, transmembrane domain and C-terminal kinase domain. PINK1 is imported into mitochondria and anchored into the...