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Skip to Search Results- 1 Dumonte, Charles
- 1 Preto, Jordane
- 1 Spasevska, Ivana
- 1 Tuszynski, Jack A
- 1 Winter, Philip
- 1 Wong, Gane K-S
- 2Oncology, Department of
- 2Oncology, Department of/Medical Oncology
- 2Graduate and Postdoctoral Studies (GPS), Faculty of
- 2Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Mechanical Engineering, Department of
- 1Mechanical Engineering, Department of/Journal Articles (Mechanical Engineering)
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Conformational analysis of galactofuranosides using NMR spectroscopy and computational chemistry
DownloadFall 2012
The five-membered ring, or furanose, form of galactose is not found in mammalian systems. However, it is commonly found in pathogenic organisms, including Aspergillus fumigatus, Campylobacter jejuni, and Mycobacterium tuberculosis. In many of these organisms, galactofuranose (Galf) is essential...
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Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Ayoub, Ahmed T , Dumonte, Charles, Wong, Gane K-S, Preto, Jordane, Tuszynski, Jack A, Spasevska, Ivana, Winter, Philip
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...
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Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
Download2017-08-02
Spasevska, Ivana , Wong, Gane K.-S. , Preto, Jordane , Winter, Philip , Dumontet , Charles , Ayoub, Ahmed T. , Tuszynski, Jack A.
Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While C. autumnale produces a potent cytotoxin, colchicine, and...