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Skip to Search Results- 5Chan, Catherine B.
- 5Wheeler, Michael B.
- 4Koshkin, Vasilij
- 3Gänzle, Michael G.
- 2Cox, Faith
- 2Guan, Leluo
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2011
Willing, Benjamin P., Finlay, B. Brett , Thanachayanont, Teerawat, Croxen, Matthew, Vacharaksa, Anjalee
Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E. coli infections) vary between mice strains, from mild...
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Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammation
Download2013
Selinger, L. Brent, Inglis, G. Douglas, Uwiera, Richard R. E., Lone, Abdul, Xu, Yong
Background Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies...
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2010-01-01
Inglis, G. Douglas, Kastelic, John, Uwiera, Richard R. E.
Catheterized intestinal loops may be a valuable model to elucidate key components of the host response to various treatments within the small intestine of ruminants. We examined whether catheterizing ileal loops in sheep affected the overall health of animals and intestinal function, whether a...
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Comparative genomics of Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations
Download2015
Zhao, Xin, Gänzle, Michael G., Lin, Xiaoxi B., Zheng, Jinshui
Lactobacillus reuteri is a dominant member of intestinal microbiota of vertebrates, and occurs in food fermentations. The stable presence of L. reuteri in sourdough provides the opportunity to study the adaptation of vertebrate symbionts to an extra-intestinal habitat. This study evaluated this...
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Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative study
Download2015
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
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2004
Zhang, Chen-Yu, Chan, Catherine B., Koshkin, Vasilij, Wheeler, Michael B., Lowell, Bradford B., Joseph, Jamie W., Saleh, Monique C., Sivitz, William I.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
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Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic α-cells
Download2005
Chan, Catherine B., Wheeler, Michael B., Asghar, Zeenat, Diao, Jingyu
The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic β-cells. However, much less is known about the role of the IR in α-cells. To assess the role of the IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency small...
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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Download2010
Kuo, Ming-Shang, Dyck, Jason R. B., Sletten, Torunn, Proctor, Spencer D., Jacobs, René L., Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kennedy, Brian P., Zhao, Yang, Vance, Dennis E., Koonen, Debby P. Y., Su, Brian
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic...
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Increased rate of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats
Download2001
Arumugam, Yoga, Luiken, Joost J. F. P., Dyck, David J., Bonen, Arend, Tandon, Narendra N., Pelsers, Maurice M. L., Bell, Rhonda C., Turcotte, Lorraine P., Glatz, Jan F. C.
Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only...
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Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
Download2012
Rang, Sara, Roos, Stefan, Phillipson, Mia, Holm, Lena, Dicksved, Johan, Willing, Ben P., Petersson, Joel, Schreiber, Olof
Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS)-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective...