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Skip to Search Results- 6Hepatitis C Virus
- 3Lipid Metabolism
- 2Triacylglycerol
- 1 Carnitine Palmitoyltransferase 1
- 1ADAM17
- 1Adaptive Immunity
- 1Capitanio, Juliana S.
- 1Greer, Michael S
- 1Johnson, Janelle L
- 1Kilic, Tolga
- 1Neufeldt, Christopher J
- 1Nourbakhsh, Mahra
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A role for the nuclear transport machinery in supporting positive-strand RNA virus infection and in regulating innate immune responses
DownloadSpring 2015
In eukaryotic cells, the genetic material is encapsulated in a double lipid membrane layer to form the nuclear compartment. This double membrane layer, termed the nuclear envelope, is fenestrated by pores, which are occupied by proteinaceous gateway structures termed nuclear pore complexes...
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Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
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Huh7.5 Cells Grown in Human Serum as a Model to Study the Effects of Hepatitis C Virus Infection on Lipid Catabolism
DownloadSpring 2018
Our goal is to study the additional elements of the mechanism of steatosis underlying hepatitis C virus (HCV) infection. Human hepatoma Huh7.5 cells cultured in human serum (HS) were used as a model to study the development of steatosis. Huh7.5 cells grown in HS media were chosen to study the...
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Fall 2015
Hepatitis C virus (HCV) leads to chronic infection in the majority of infected patients presumably due to failure or inefficiency of the immune responses generated. Both antibody and cellular immune responses have been suggested to be important in viral clearance. Non-replicative adenoviral...
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Investigation of the Molecular Mechanisms That Determine Isolate-Specific, Antibody-Mediated Neutralization of HCV infectivity
DownloadFall 2018
It is estimated that there are about 1.75 million new Hepatitis C Virus (HCV) infections per year worldwide and around 20% will develop liver cirrhosis or liver cancer if left untreated. Direct acting antiviral drugs are available for the treatment of HCV with success rates of over 90%. But...
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Fall 2017
The nucleus is a hallmark of eukaryotic cells. It segregates the genetic material from the cytoplasm. The nucleus is encapsulated by the nuclear envelope which is perforated with nuclear pore complexes (NPCs), macromolecular structures formed by proteins termed nucleoporins (Nups). NPCs and...
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Role of TG Lipases, Arylacetamide Deacetylase and Triacylglycerol Hydrolase, in Hepatitis C Virus Life Cycle
DownloadSpring 2013
Hepatitis C virus (HCV) is a major cause of chronic liver disease, including liver steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. It has become apparent that the targeting of lipid droplets (LDs) by the HCV core protein and the Very Low Density Lipoprotein (VLDL) secretory pathway...
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Type-1 Brassica napus Diacylglycerol Acyltransferases: Enzyme Characterization and Molecular Tools for Increasing Storage Lipid Production in Yeast
DownloadFall 2015
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA- dependent biosynthesis of triacylglycerol (TAG). The level of DGAT activity may have a substantial effect on the flow of carbon into TAG in many organisms. In plants, yeast, and animals, two families of...