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Development and partial validation of a bioanalytical assay for the detection of a novel bone-targeting parathyroid hormone conjugate using metal-free LC-MS/MS
DownloadFall 2020
In an effort to address shortcomings with current drug treatments for osteoporosis (OP) and improve the efficacy of human parathyroid hormone (hPTH(1-34)), we have employed a bisphosphonate-conjugation strategy by tethering hPTH(1-34) to a non-nitrogenated bisphosphonate (BP) moiety (BP-PTH) in...
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