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Skip to Search Results- 1Arvanitidis, Anastasia P
- 1Budd, Alexandra
- 1Connor, Steven
- 1Engin, Elif
- 1Greenberg, Anastasia
- 1Hrybouski, Stanislau
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NOREPINEPHRINE-MEDIATED SYNAPTIC PLASTICITY: A NOVEL SIGNALING DIALOGUE BETWEEN RECEPTORS AND NUCLEUS
DownloadSpring 2014
Norepinephrine (NE) helps in the consolidation and retention of memories of emotionally charged events. However, the pathway from membrane receptors to nucleus in noradrenergic signaling in the brain is not completely understood. The cyclic AMP-PKA pathway is one of the most studied signaling...
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Fall 2015
Despite considerable research progress towards characterizing the neurobiology of anxiety, the focus on putative behavioral markers and the absence of a common behavioural/neurobiological signature for the different classes of anxiolytic drugs have potentially slowed research into the neural...
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Fall 2018
Approximately 50 million people worldwide suffer from epilepsy, a chronic neurological disorder characterized by recurrent seizures. While most patients with epilepsy will respond to anticonvulsant medications, approximately one third are found to have drug resistant epilepsy. Mesial temporal...
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The Effects of a Western Diet on Stroke Severity and Functional Outcome Following Global Ischemia in Rats
DownloadFall 2009
The present thesis investigated the effects of a western diet (WD) on cell death and functional outcome following global ischemia in rats. Experiment 1 assessed the effects of a 60-day WD regimen on temperature, activity and glucose levels in normal rats. Experiment 2 evaluated the influence of a...
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Fall 2009
Anxiety disorders are the most prevalent of all psychiatric conditions. However, current pharmacological treatments for anxiety disorders are characterized by one or more of the following deficiencies: 1) unwanted side effects, 2) partial efficacy, 3) addictive potential, and 4) delayed onset of...
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The Functional Role of Hippocampal Subregions and Subfields: A High-Resolution fMRI Study of Memory
DownloadFall 2017
The involvement of the hippocampus in episodic memory is well accepted. What is often overlooked is the involvement of hippocampal subfields and subregions. The hippocampal subfields Cornu Ammonis (CA), Dentate Gyrus (DG) and Subiculum (Sub) are cellularly distinct areas that communicate...
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The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience
DownloadFall 2009
This thesis examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. Rats received either dorsal or ventral hippocampal infusions of Lidocaine, muscimol or saline, before or after exposure to an...