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Fall 2020
Introduction The Dlx1/Dlx2 double knockout (DKO) mouse exhibits major defects in forebrain development including a block in differentiation and migration of GABAergic interneurons from the subpallium to the cortex. In addition, the Dlx1/Dlx2 DKO mouse generates more oligodendrocyte progenitor...
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Roles for Transcription Factors and Signaling Pathways in Hindbrain Segmentation and Ventricle Morphogenesis
DownloadFall 2018
During development, expression and localization of transcription factors and transcriptional co-regulators must be tightly controlled, and in turn they are required to regulate cellular identity and cellular processes. Often this involves complex interactions with signaling pathways. We are...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
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Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...