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Skip to Search Results- 1Abu Alrub, Osama Y
- 1Agellon, Luis B.
- 1Chow, Ava Kalyca
- 1Clark, A.M.
- 1Fliegel, Larry
- 1Gamble, James.
- 13Graduate and Postdoctoral Studies (GPS), Faculty of
- 13Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Biochemistry, Department of
- 1Biochemistry, Department of/Journal Articles (Biochemistry)
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COUP-TF1 antagonizes Nkx25-mediated activation of the calreticulin gene during cardiac development
Download2001-01-01
Guo, Lei, Lynch, Jeffrey, Nakamur, Kimitoshi, Fliegel, Larry, Kasahara, Hideko, Izumo, Seigo, Komuro, Issei, Agellon, Luis B., Michalak, Marek
Calreticulin, a Ca2+ binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of...
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2002
Clark, A.M., MacIntyre, P.D., Sharp, C.
Access to health care should be determined by clinical need and not by age. Older people form an increasing proportion of the general population and of those with coronary heart disease, but compared with younger people they are less likely to be invited for cardiac rehabilitation programmes and...
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Intracellular regulation of matrix metalloproteinase-2 activity: the roles of caveolin-1 and troponin I phosphorylation
DownloadFall 2010
Matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets and actions within the cardiac myocyte. In ischemia/reperfusion (I/R) injury, MMP‐2 is activated and degrades troponin I (TnI) and α‐actinin. The regulation of intracellular MMP‐2 activity is relatively unknown and is thus...
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Spring 2011
The traditional PI3K pathway relies on agonist mediated stimulation of PI3Kα through RTKs and PI3Kγ through GPCRs, which stimulate downstream enzymes such as Akt. This pathway has been found to be important in cardiomyocytes and cardiofibroblasts for regulating cardiac morphology and function....
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Spring 2011
Technological advances for treatment of congenital heart disease (CHD) have led to decreases in mortality over the past thirty years. Persistent morbidity into adolescence and adulthood necessitates regular medical follow-up and the influence of ongoing physical health issues on the teens...
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Fall 2012
Heart disease is a leading cause of morbidity and mortality in the world with a growing prevalence in a variety of manifestations. Many of the events that occur in the heart during the progression of disease have been explored to identify a causative mechanism to develop effective treatments and...
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Fall 2012
The heart requires an uninterrupted supply of fuels to sustain its physiological function. Fatty acids are the predominant substrates and endogenous triglyceride turnover contributes significantly to fatty acid oxidation. Lipins are cytosolic, bifunctional enzymes involved in both glycerolipid...
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Fall 2014
Cardiac Fatty acids β-oxidation (FAO) markedly increases during maturation and become the major source of energy for the adult heart. However, excessive rates of FAO can compromise cardiac function in obesity, diabetes, and heart failure. Lysine acetylation has recently been identified as a...