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Challenges for Resource Allocation, Decision Making and Consideration of Social Values for Screening, Diagnosis and Treatment of Hepatitis C in Canadian Populations
DownloadFall 2018
Introduction: Health care system decision makers face challenges in allocating resources for screening, diagnosis and therapies for hepatitis C, caused by the highly infectious and blood borne hepatitis C virus (HCV) (WHO, 2014). Approximately 240,000 individuals are infected with HCV in Canada...
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Huh7.5 Cells Grown in Human Serum as a Model to Study the Effects of Hepatitis C Virus Infection on Lipid Catabolism
DownloadSpring 2018
Our goal is to study the additional elements of the mechanism of steatosis underlying hepatitis C virus (HCV) infection. Human hepatoma Huh7.5 cells cultured in human serum (HS) were used as a model to study the development of steatosis. Huh7.5 cells grown in HS media were chosen to study the...
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Immortalized human hepatocyte, an alternate model for the study of the propagation of HCV in vivo and in vitro
DownloadSpring 2011
The chimeric Alb-uPA SCID mouse that has been transplanted with human hepatocytes is a model to facilitate in vivo study of HCV. We explored further development of the model by using repopulation with immortalized human hepatocytes (IHH) in place of primary human hepatocyte (PHH) transplantation...
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Fall 2013
The hepatitis C virus leads to chronic infection in the majority of infected individuals; however, in a minority of patients, acute infection is followed by viral clearance. The immune correlates of viral clearance are not yet clear, but have been extensively investigated, suggesting the role of...
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Regulation of HCV Cell-to-Cell Spread by ADP-ribosylation factor 1-Dependent Regulation of Cytosolic Lipid Droplet Homeostasis
DownloadSpring 2018
Hepatitis C virus (HCV) infects cells via cell-free virions by direct cell-to-cell transmission. Entry of cell-free HCV virions has been fairly well-characterized. Several host factors involved in this process have been identified, including the cell surface receptors, tight junction molecules,...