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Spring 2016

Fillmore, Natasha

Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...

Fall 2018

Altamimi, Tariq Rushdi

Energy substrate utilization in the heart is both altered by- and contributes to- the pathophysiology of heart disease. For example, there is an increased reliance on fatty acid oxidation for energy production in conditions such as diabetes, diabetic cardiomyopathy, and during reperfusion of...

Spring 2013

Sidhu, Vaninder K.

Ischemic heart disease and pulmonary arterial hypertension are often accompanied by a drastic change in myocardial energy metabolism that favors fatty acid oxidation and glycolysis, respectively, over glucose oxidation. This form of energy production is both inefficient and detrimental to the...