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Fall 2017
Flaviviruses are important human pathogens that have an enormous impact on global health. Examples that have been studied in my research include dengue virus (DENV), West Nile virus (WNV) and most recently, Zika virus (ZIKV). Currently, there are very few vaccines against or therapeutic...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Distinct Roles of Class 1 PI3K Isoforms in the Regulation of Beta Cell Exocytosis and Insulin Secretion
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Type 2 diabetes (T2D) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic beta cell. The incidence of T2D is rising worldwide at an alarming rate. An increase in population growth, increased prevalence of obesity, and an aging population...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Spring 2016
Flaviviruses, such as West Nile virus (WNV), Powassan virus (POW), and Saint Louis encephalitis virus (SLEV), are significant pathogens capable of causing serious neurological disease in both humans and animals. Despite their relevance to human health, treatment and vaccines for these viruses...
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Spring 2013
AKT inhibits apoptosis and stimulates cap-dependent translation by phosphorylating key downstream cellular proteins. Many viruses therefore activate the PI3-kinase-AKT signaling pathway to promote cell survival and viral protein synthesis. HSV-1 activates AKT during lytic infection and the...
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Investigating the role of G-protein coupled receptor (GPCR) signaling as a potential target for anti-angiogenic therapy
DownloadFall 2021
Angiogenesis is an essential process for normal growth and development whereby new blood vessels are formed from pre-existing ones. The balance between pro-angiogenic and anti-angiogenic growth factors is critical to maintain normal physiological condition. Prolonged activation of angiogenesis...
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Spring 2020
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, while ischemic heart disease (IHD) dominates the cause of CVD mortality. Following myocardial infarction (MI), the heart experiences a series of structural and functional changes, termed post-infarction...
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Spring 2011
The traditional PI3K pathway relies on agonist mediated stimulation of PI3Kα through RTKs and PI3Kγ through GPCRs, which stimulate downstream enzymes such as Akt. This pathway has been found to be important in cardiomyocytes and cardiofibroblasts for regulating cardiac morphology and function....