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Skip to Search Results- 1Achtymichuk, Karly A
- 1Afhami, Shima
- 1Alsaif, Maha
- 1Eskin, Maxim
- 1MacDonald, Krista M
- 1Mercer, Rebecca E
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Characterization of the Protein Interaction Networks of Necdin and MAGEL2: Insight into How Loss of These Proteins Contributes to Neurodevelopmental Disease
DownloadFall 2020
Prader-Willi Syndrome (PWS) is a neurocognitive developmental disorder that is caused by the deletion or inactivation of paternal genes in the chromosomal region 15q11-q13. The MAGEL2 and NDN (encoding necdin) genes are within the deleted region. Individuals with PWS tend to be obese due to...
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Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
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Drug Exposure Definition and Healthy User Bias Impacts on the Evaluation of Oral Anti Hyperglycemic Therapies
DownloadFall 2017
Accurate estimation of medication use is an essential component of any pharmacoepidemiological research as exposure misclassification will threaten study validity and lead to spurious associations. Many pharmacoepidemiological studies use simple definitions, such as the categorical “any versus no...
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Influenza Vaccination in Patients with Diabetes: Exploration of the Healthy User in Pharmacoepidemiology Studies
DownloadFall 2015
Pharmacoepidemiologic studies of preventive medications or therapies are prone to the healthy user bias, as patients who are prescribed and adhere to preventive medications/therapies are likely different than patients not receiving these medications in multiple aspects of their lives. These...
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Profiling the Bacterial and Fungal Gut Microbiome of Children with and without Prader-Willi Syndrome (PWS)
DownloadFall 2020
Obesity is a complex multifactorial disease that has a large array of direct (e.g. altered metabolic and inflammatory profile) and indirect (e.g. mental health concerns etc.) consequences on health and is associated with increased morbidity and mortality. Prader-Willi Syndrome (PWS) is the most...
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The Impact of Dietary Protein on Appetite-Regulating Hormones and Energy Metabolism in Children with Prader-Willi Syndrome
DownloadSpring 2020
Prader-Willi syndrome (PWS) is a unique model of childhood obesity characterized by disordered satiety. The excessive weight gain caused by an imbalance between energy intake and expenditure associated with PWS is of concern to healthcare professionals and caregivers who acknowledge that weight...
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Fall 2012
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder that results from the loss of several paternally expressed genes on chromosome 15q11-q13. People with PWS have an array of phenotypes including hypotonia and early failure to thrive, hypogonadism and infertility, growth hormone...
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Vitamin D Status and Markers of Cardiometabolic and Liver Disease Risk in Childhood Obesity
DownloadSpring 2017
Vitamin D insufficiency is highly prevalent in children (up to 40%), particularly in northern climates such as Alberta, due to reduced sunlight exposure and low intake. Although suboptimal vitamin D status and metabolic dysregulation are commonly observed in obesity, little is known about the...