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Skip to Search Results- 1Achtymichuk, Karly A
- 1Almukainzi, May Khalifah
- 1Chen, Christopher B
- 1Dubois, Tyler
- 1Eskin, Maxim
- 1Gabr,Raniah Q
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Drug Exposure Definition and Healthy User Bias Impacts on the Evaluation of Oral Anti Hyperglycemic Therapies
DownloadFall 2017
Accurate estimation of medication use is an essential component of any pharmacoepidemiological research as exposure misclassification will threaten study validity and lead to spurious associations. Many pharmacoepidemiological studies use simple definitions, such as the categorical “any versus no...
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Influenza Vaccination in Patients with Diabetes: Exploration of the Healthy User in Pharmacoepidemiology Studies
DownloadFall 2015
Pharmacoepidemiologic studies of preventive medications or therapies are prone to the healthy user bias, as patients who are prescribed and adhere to preventive medications/therapies are likely different than patients not receiving these medications in multiple aspects of their lives. These...
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International Comparison of Time to Treatment Intensification and Rates of Complications in Metformin Monotherapy Treated Type 2 Diabetes Patients
DownloadFall 2018
Type 2 diabetes mellitus is a progressive disease which affects many people in Canada and the United States, and the prevalence of type 2 diabetes is only expected to increase in the future. Pharmacological interventions are a cornerstone of the management of type 2 diabetes as they help to...
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The application of computer simulation to investigate drug absorption and bioavailability in disease states
DownloadFall 2015
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
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The Effect of Metformin, Flutamide and Dietary Nicotinic Acid on Dyslipidemia and Cardiometabolic Risk in the JCR:LA-cp Rodent Model of PCOS
DownloadFall 2014
Polycystic ovary syndrome (PCOS) is a highly prevalent metabolic-endocrine disorder affecting up to 18% of adolescent and adult females in their reproductive years. PCOS is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes. Atherogenic dyslipidemia occurs in...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
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Fall 2016
Relative to those without diabetes, individuals with type 2 diabetes have an increased risk of several cancers, but a decreased risk of prostate cancer. While metformin may reduce the risk of some cancers, it may not reduce the risk of prostate cancer. However, race/ethnicity may modify...