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2003

Chan, Catherine B., Wang, Xiaolin, Koshkin, Vasilij, Wheeler, Michael B., Scherer, Philipp E.

Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial oxidative phosphorylation is a main link between glucose metabolism and insulin secretion, in the present work we...

Fall 2019

Morgan, Andrew

Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...

Fall 2013

Nagendran, Jeevan

All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...

Spring 2018

Fontaine, Melanie A

Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...

2016-11-04

Nieuwendyk, Laura M., Vallianatos, Helen, Belon, Ana Paula, Nykiforuk, Candace I.J.

People's perceptions of local food environments influence their abilities to eat healthily. PhotoVoice participants from four communities in Alberta, Canada took pictures of barriers and opportunities for healthy eating and shared their stories in one-on-one semi-structured interviews. Using a...

2009

O'Donovan, John T., Navabi, Alireza, Kaut, A. H. E. E., Spaner, Dean, Mason, Heather E.

Wheat (Triticum aestivum L.) variety mixtures represent a relatively unexplored avenue for maintaining and stabilizing yield for both organic and conventional producers. The present study examined the responses of three Canadian western red spring wheat varieties in sole crop and in variety...

2014-12-09

CIHR Institute of Nutrition, Metabolism, and Diabetes

The CIHR Institute of Nutrition, Metabolism, and Diabetes recently hosted an information webinar describing the program, what funds are available, the four funding pools, collaborators and partners, deadlines and evaluation criteria. The webinar slides can now be downloaded.

1996

Cool, N., Hudson, R.J.

Energy requirements of moose (AIces alces) and wapiti (Cervus elaphus) calves were compared from December to February to determine whether metabolic requirements were lower in a boreal-adapted than in a parkland-adapted wild cervid. Eight calves of each species were divided equally into groups...

Fall 2016

Clifford, Alexander M

Hagfish feed on putrefied carrion, which poses several environmental challenges to the scavenger including hypoxia (Low PO2), hypercapnia (high PCO2) and high environmental ammonia (HEA). To any other organism, these conditions would be physiologically challenging; however, hagfish seem to have...

Spring 2024

Rekhi, Umar

Background and Objective High-fat Western diets have been linked to the dysregulation of fatty acids (FA) and glucose intake in tissues, resulting in adverse metabolic outcomes such as obesity, insulin resistance, and atherosclerosis. There is a pressing need for new therapeutic approaches to...