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Fall 2021
This thesis investigates how to bolster activity dependent neuronal plasticity in conjunction with rehabilitative motor therapy to increase recovery following spinal cord injury in rats. My work focuses primarily on the injured corticospinal tract (CST) and how boosting intracellular signalling...
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Investigating the Mechanism of Conditioning Electrical Stimulation: Identifying Key Parameters and Signaling Pathways
DownloadFall 2024
Despite timely surgical intervention, regeneration following peripheral nerve injury remains insufficient for adequate functional recovery. Thus, new therapeutic interventions are necessary. Traditionally, electrical stimulation has been delivered postoperatively to promote functional recovery...
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Towards Clinical Testing of Intraspinal Microstimulation for Restoration of Walking after Spinal Cord Injury
DownloadSpring 2019
The overall goal of this thesis was to advance intraspinal microstimulation (ISMS) towards clinical testing for the purpose of restoring walking after spinal cord injury. ISMS implants focus on restoring mobility after spinal cord injury by activating the intact spinal motor networks below the...