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- 8Graduate and Postdoctoral Studies (GPS), Faculty of
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- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science)
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Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzine
DownloadFall 2017
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary clinical consequences of MS, the disease is also...
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CNS Inflammasome Activation and Pyroptosis in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
DownloadFall 2019
McKenzie, Brienne Alexandra Furfaro
Multiple sclerosis (MS) is a progressive and incurable demyelinating disease of the central nervous system (CNS). The neuropathogenesis of MS and its prototypic animal model, experimental autoimmune encephalomyelitis (EAE), is defined by persistent neuroinflammation, involving the activation of...
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Investigating early life microbial and host transcriptomic dynamics in the bovine gastrointestinal tract
DownloadSpring 2019
There is increasing concern surrounding the ability of livestock industries to meet the needs of the rising global population. The gastrointestinal microbiota of ruminants plays a critical role in feed degradation, host energy supply, but is also a substantial source of anthropogenic greenhouse...
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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...
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Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...
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Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
Download2009
Baracos, Vickie E., Xue, Hongyu, Sawyer, Michael B., Field, Catherine J
Infectious complications are a major cause of morbidity and mortality from dose-intensive cancer chemotherapy. In spite of the importance of intestinal bacteria translocation in these infections, information about the effect of high-dose chemotherapy on gut mucosal immunity is minimal. We studied...
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The glutamate transporters' role in neuropathic pain and cognitive deficits in an animal model of multiple sclerosis
DownloadFall 2013
Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by demyelination, inflammation and axonal injury. Chronic pain and cognitive deficits affect a large percentage of MS patients. While a number of animal models are available to study the pathophysiology of...
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Fall 2023
The immune system interacts reciprocally with the nervous system in order to accomplish facets of innate immunity via various mechanisms including toll-like receptors (TLRs). TLR activity leads to the release of cytokines which can effect acute and chronic pain states by promoting afferent neuron...
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Spring 2016
Maintenance of the gut health of calves is vital because enteric infections are associated with high mortality during the pre-weaned period. The small intestine is the primary site of many enteric infections and plays an important role in protecting the host from pathogenic infection through both...