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- 2Gene therapy
- 1Antithrombotic polymers
- 1Cationic polymers
- 1Cell-based therapy
- 1DNA topology
- 1Intracellular trafficking
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A Combined Computational and Experimental Investigation of Polynucleotide Binding Polymers for Therapeutic Applications
DownloadFall 2017
Polynucleotide binding polymers have a wide range of therapeutic applications including delivery systems for therapeutic polynucleotides, and antithrombotic drugs for extracellular nucleic acid-mediated thrombogenic events. This dissertation explores polynucleotide binding polymers in these two...
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Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier
DownloadFall 2012
This thesis work is aimed at addressing some of the fundamental questions surrounding the intracellular fate of plasmid DNA in clinically-relevant primary cells, when delivered with lipid-modi!ed cationic polymers as gene carriers. We developed an optimized procedure for the transfection of...
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