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Implications of genetic diversity on expression of LILRB1 in Natural Killer cells and susceptibility to HCMV infection in transplant patients
DownloadFall 2016
Leukocyte Ig-like Receptor 1 (LILRB1) is an inhibitory receptor expressed on a number of immune cells. The expression profile on NK cells is variable between people, with a range of 25-80% of NK cells expressing LILRB1. We previously uncovered a correlation between genotype within the 5’ end of...
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Investigating the differential effects of LILRB1 natural variants on interaction with MHC-I and UL18
DownloadFall 2022
The Leukocyte immunoglobulin-like receptor B1 (LILRB1) is widely expressed throughout human immune cells of lymphoid and myeloid origins. It is also associated with viral infection, autoimmune diseases and cancer. LILRB1 regulates immune responses through broad interaction with major...
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Investigation of an enhancer-based regulation of LILRB1 gene and the differential functions of LILRB1 variants in natural killer cells
DownloadFall 2020
Human cytomegalovirus (HCMV) causes severe disease in immunocompromised people such as transplant patients. NK cells are crucial in controlling HCMV whereas HCMV developed multiple strategies to evade NK cell surveillance. HCMV encodes a human MHC-I homolog called UL18 to target an inhibitory...