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Fall 2009
First-line treatment of breast and other cancers with Taxol is compromised by resistance in up to 40% of patients. To improve chemotherapy, it is vital to understand how Taxol resistance develops and to overcome this. Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...