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- 58Graduate and Postdoctoral Studies (GPS), Faculty of
- 58Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 2Field, Catherine (Agricultural, Food and Nutritional Science)
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Contributions to chronic disease prevention and control: studies among the Kivalliq Inuit since 1990
Download2003-12-01
"A population-based health interview and examination survey of 8 Inuit communities in the Kivalliq region of Nunavut, Canada, during the early 1990s has resulted in an increased understanding of the burden and extent of cardiovascular diseases and diabetes and their risk factors such as genetics,...
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Fall 2012
Establishing mixed hematopoietic chimerism is a promising approach to develop donor-specific tolerance to transplanted organs. Establishing tolerance may eliminate the need for long-term immunosuppressive therapy, prevent chronic rejection and in the case of Type 1 Diabetes (T1DM), reverse...
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Delineation of molecular mechanisms of intestinal calcium absorption during postnatal development
DownloadFall 2021
Infants and children must maintain a positive calcium balance for appropriate growth. Evidence suggests that adaptations in intestinal absorption of calcium are the major determinant of this net balance. However, the molecular details of the pathways mediating this increased absorption at a young...
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Determinants of healthy eating in Aboriginal peoples in Canada: The current state of knowledge and research gaps
Download2005-01-01
Aboriginal peoples are the original inhabitants of Canada. These many diverse peoples have distinct languages, cultures, religious beliefs and political systems. The current dietary practices of Aboriginal peoples pose significant health risks. Interventions to improve the nutritional status of...
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2019-12-10
Pepper, Andrew, Korbutt, Gregory
NFRF Exploration awarded in 2020: While the global incidence of type 1 diabetes (T1D) continues to rise, it is now clear that transplantation of human pancreatic islets of Langerhans, into the patients’ liver, can successfully restore glycemic control. Despite marked progress in clinical islet...
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Diabetes and Influenza-Attributable Illness: The Rationale for Targeted Influenza Vaccinations in Adults with Diabetes
DownloadFall 2012
While guidelines for seasonal influenza vaccinations single out working age (< 65) adults with diabetes, vaccination rates in this group remain below national targets. Historically, there has been limited evidence to support these guidelines. This dissertation comprises four studies investigating...
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Diabetes care and management in Indigenous populations in Canada – Summary report of a pan-Canadian policy roundtable November 1, 2017
Download2018-01-29
Institute of Health Economics, Craig, Rodger
This report provides a summary of the proceedings from the IHE roundtable on diabetes care and management in Indigenous populations in Canada, held on November 1, 2017. The roundtable aimed to: discuss and share learnings and promising practices from successful community-led diabetes programs,...
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2000-04-01
Sellers, Elizabeth, Eisenbarth, George, Young, T. Kue, Dean, Heather J.
"Type-2 diabetes is increasing in aboriginal children and adolescents and must be distinguished from type-1 diabetes in this population. The absence of diabetes-associated autoantibodies supports the clinical impression of type-2 diabetes in the affected members of this population." (as cited in...