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Fall 2019
Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...
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The human neuraminidase enzyme, NEU3, regulates integrin-mediated cell migration via changes in glycolipid composition
DownloadFall 2013
The human neuraminidase enzyme, NEU3, is known to cleave sialic acid from ganglioside substrates. However, the biological effects of this cleavage are not clearly understood. This thesis describes our studies of the regulation of β1-integrins by neuraminidase enzymes, and the role of gangliosides...