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Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
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SLC4A11 in Blinding Endothelial Corneal Dystrophies: Characterization, Molecular Defect and Potential Therapeutic Strategy
DownloadFall 2019
Endothelial Corneal Dystrophies (ECD), genetic blinding diseases with a heterogeneous pathophysiology, are the leading cause of endothelial keratopathy (corneal transplants). Patients manifest symptoms, including corneal edema with increased corneal thickness and loss of corneal endothelial cells...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...