Search
Skip to Search Results- 4Matrix metalloproteinase
- 2Caveolin
- 2Troponin I
- 1Acute coronary syndrome
- 1Angiotensin II
- 1Apolipoprotein
-
Building Evidence to Assess a Drug Safety Signal: the Association between Sulfonylureas and Adverse Cardiovascular Events
DownloadFall 2015
All drugs have the potential to cause adverse events that can result in hospitalization or death. In order to protect the public health, it is critical to employ methods to detect and assess adverse drug events in a timely manner. One of the most controversial and long standing drug safety issue...
-
Intracellular regulation of matrix metalloproteinase-2 activity: the roles of caveolin-1 and troponin I phosphorylation
DownloadFall 2010
Matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets and actions within the cardiac myocyte. In ischemia/reperfusion (I/R) injury, MMP‐2 is activated and degrades troponin I (TnI) and α‐actinin. The regulation of intracellular MMP‐2 activity is relatively unknown and is thus...
-
Spring 2011
Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...
-
Regulation of collagen type I production by ionizing radiation and transforming growth factor-β1 in primary human skin fibroblasts derived from early stage breast cancer patients in relation to acute radiation-induced toxicity
DownloadFall 2011
Regulation of collagen type I (CI) in fibroblasts is critical for the onset and development of skin toxicities induced by radiation therapy (RT). Transforming growth factor beta-1 (TGF-β1) and vascular endothelial growth factor (VEGF) promote CI synthesis, while its degradation is modulated by...
-
Spring 2024
Matrix metalloproteinase 2 (MMP2), also known as gelatinase A or 72 kDa type IV collagenase, is a member of a family of 25 different Zn2+-dependent endopeptidases that cleave a broad range of proteins including extracellular matrix proteins (such as collagens, laminin, fibrillin and aggrecan),...