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Fall 2017
The voltage-gated KCNQ1/KCNE1 potassium ion channel plays a key role in maintaining the heart rhythm. An active channel generates the slow delayed rectifier (IKs) current in the heart. Both loss-of-function and gain-of-function mutations in KCNQ1 or KCNE1 are linked to many heart-related...
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Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity
DownloadSpring 2013
Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective anticancer agent whose major limiting side effect is cardiotoxicity. Of importance, several studies...
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