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- 1C. jejuni
- 1Chemistry
- 1Enzymatic and chemo-enzymatic synthesis
- 1Glycoconjugate vaccine
- 1Oligosaccharide
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Chemical, Enzymatic and Chemo-enzymatic Synthesis of Complex Oligosaccharides as Probes of Glycan Functions
DownloadSpring 2016
Carbohydrates, an essential class of biomolecules, mediate a variety of biological processes. Recent advances in chemical, enzymatic and chemo-enzymatic synthesis have facilitated access to an increasing number of structurally well-defined oligosaccharides. These molecules are serving as...
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Exploration of specific carbohydrate epitopes in their native habitat with the Staudinger ligation
DownloadFall 2011
Glycans modulate biological processes and play a vital role in the function of receptors. However, the structure and functions of glycans are often obscured due to the heterogeneity of these structures. We hypothesize that the function of a specific carbohydrate epitope can be elucidated by...
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Studies Towards Understanding the Biosynthesis of Methyl Phosphoramidates found in Campylobacter jejuni
DownloadFall 2016
The human pathogen Campylobacter jejuni is the leading cause of food-borne gastroenteritis, causing more foodborne illnesses than Salmonella, Shigella, and Listeria combined. Of the approximate 5.3 million people infected every year in North America alone, approximately 1/1000 will develop the...
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The Design, Synthesis and Evaluation of Multivalent Heterobifunctional Ligands Specific for Shiga Toxin 1 and Shiga Toxin 2
DownloadSpring 2014
Hemolytic uremic syndrome (HUS) is a potential life-threatening condition caused by infection with Shiga toxin-producing Escherichia coli O157:H7. There are two major types of Shiga toxins, namely, Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2), of which, Stx2 is clinically most closely associated...