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Skip to Search Results- 1Abdulsalam Alharbi
- 1Al Lawati, Hanan M
- 1Alshamsan, Aws
- 1Binkhathlan, Ziyad
- 1Elshaikh, Asya S Egweda
- 1Garg, Shyam M
- 5Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Afsaneh Lavasanifar
- 1Afsaneh Lavasanifar, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1El-Kadi, Ayman (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
Results for "departments_tesim:"Faculty of Pharmacy and Pharmaceutical Sciences""
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Fall 2010
In many tumors, persistently-active signal transducer and activator of transcription 3 (STAT3) imparts several oncogenic features such as survival, proliferation, angiogenesis, and immune escape. Therefore, STAT3 targeting in cancer and cancer-exposed dendritic cells (DCs) is important for cancer...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Development of Poly(ethylene oxide)-block-poly(ε-caprolactone) based Micelles for Tumor Targeted Drug and siRNA Delivery
DownloadFall 2015
The use of nanotechnology has made significant advancements in cancer diagnosis and treatment. Polymeric micelles are a relatively new generation of nanocarriers mostly intended for the delivery of hydrophobic drugs. In this thesis, our objective was to develop an optimized polymeric micellar...
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Preliminary validation of a computer-based approach to find new lead molecules targeting the oncogenic Forkhead box M1 transcription factor
DownloadFall 2017
The upregulation of the forkhead box M1 (FOXM1) transcription factor is directly correlated with cancer initiation, invasion, and drug resistance. Because the overexpression of FOXM1 is considered an important factor in carcinogenesis, this protein could be a relevant drug target in cancer...
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Rational Design and Development of Nanodelivery Systems and Combination Treatments for Overcoming Chemoresistance in Solid Tumors
DownloadFall 2017
The long term goal of this research is to develop drug delivery systems and combination treatments that can overcome chemoresistance in breast cancer. Here, we attempted two different approaches: First, we tried development of polymeric micelles capable of enhanced drug delivery to tumor, while...
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Development of traceable Rituximab modified polymeric micelles for active targeting of B-cell Lymphoma
DownloadFall 2017
Abstract B-cell Non-Hodgkin Lymphoma (NHL) accounts for more than 90% of all adult cases of lymphomas and in most cases it is CD20 positive. B-cell NHL is usually treated by combination of conventional chemotherapeutics and the monoclonal antibody against CD20, rituximab. This combination regimen...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...