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- 1Endothelial Cell
- 1Endothelial Cells
- 1Endothelial Heterogeneity
- 1Gene regulation
- 1Gene-expression
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ENDOTHELIAL CELL HETEROGENEITY: A CORRELATION WITH THE VON WILLEBRAND FACTOR EXPRESSION IN DISTINCT ORGANS
DownloadSpring 2017
Endothelial cells (EC) of different organs exhibit heterogeneity in structure, function and gene expression pattern. This also extends to the pattern in which the highly endothelial-specific gene, von Willebrand Factor (VWF) is expressed. VWF is a multimeric adhesive, pro-coagulant glycoprotein...
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The mechanism of endothelial cell specific gene expression of Von Willebrand Factor in vivo
DownloadSpring 2010
In vivo analyses of the Von Willebrand Factor (VWF) promoter previously demonstrated that a fragment spanning sequences -487 to +247 targets promoter activation to brain vascular endothelial cells. This fragment is active in all embryonic vessels of transgenic mice but in adult mice its activity...
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Transcriptional regulation of von Willebrand Factor gene in response to hypoxia and in cancer cells
DownloadFall 2016
Von Willebrand Factor (VWF) is a pro-coagulant, glycosylated protein that is exclusively expressed in endothelial cells and megakaryocytes. An acute phase protein, VWF is upregulated or released from activated or injured endothelial cells. In addition, it is a carrier for factor VIII that...