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Skip to Search Results- 20Pharmacokinetics
- 6Hepatocytes
- 4Nonsteroidal anti-inflammatory agents
- 3Enantiomers
- 3Pharmacodynamics
- 2Biodistribution
- 1Al Lawati, Hanan M
- 1Anwar-Mohamed, Anwar Gamal Abd El-Naser
- 1Binkhathlan, Ziyad
- 1Carr, Robert Arthur.
- 1Corrigan, Brian W.
- 1El Sayed, Dalia
- 17Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Cell Biology
- 1Department of Chemistry
- 1Department of Medical Sciences
- 1Department of Pharmaceutical Sciences
- 1Department of Pharmacology
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Andrew Holt
- 1Dr. Brocks, Dion R (Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin ( Pharmacy and Pharmaceutical Science)
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED XENOBIOTIC METABOLIZING ENZYMES BY ARSENITE
DownloadFall 2013
Anwar-Mohamed, Anwar Gamal Abd El-Naser
Aryl hydrocarbon receptor (AhR) ligands and heavy metals are environmental co-contaminants and their molecular interaction may disrupt the coordinated regulation of AhR-dependent phase I and II drug metabolizing enzymes. As such, the effect of the heavy metal, As(III), on the AhR-regulated genes...
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Pharmacokinetic interactions of mycophenolic acid: population pharmacokinetics and a translational investigation on p-cresol mediated metabolism interaction
DownloadFall 2022
BackgroundMycophenolic acid (MPA) is a frequently used immunosuppressant after organ transplantation to prevent graft rejection. It is often prescribed concurrently with tacrolimus and corticosteroids. MPA has been associated with significant variations in plasma exposure after kidney...
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Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Hepatocytes
DownloadFall 2015
Triacylglycerol (TG) metabolism with its high-energy potential is stringently regulated. Unbalanced TG regulation, either too much TG that overwhelms cellular storage capacity or too little TG due to defects in adipogenesis, is associated with various metabolic disorders. TG can be exported from...
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The Alberta Drug Administration Modeller (ADAM): a life-size, hands-on pharmacokinetics learning tool for our future healthcare professionals
DownloadFall 2017
The processes of absorption, distribution, metabolism, and elimination (ADME) determine a drug’s pharmacokinetics (PK). Each of these processes is described with abstract modelling, and the relationships are characterised through equations and graphical analysis using both noncompartmental and...