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Spring 2013

McCracken, Allen TM

If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...

Fall 2020

Pridie, Conrad

Peroxisomes are organelles responsible for processing lipids and managing reactive oxygen species. A conserved family of genes called peroxisome biogenesis factors (Peroxin, Pex) encode proteins necessary for peroxisome biogenesis and function. In yeast and mammals, PEROXIN7 (PEX7) acts as a...

2005-09-01

Samudrala, Ram , Zheng, Hongkun , Li, Jun, Yang, Shuang , Zhang, Jianguo , Yu, Haijing , McDermott, Jason , Wang, Wen , Yang, Huanming , Jiang, Huifeng , Yang, Lei , Wang, Jian , Wong, Gane K., Kristiansen, Karsten , Su, Jianning , Yu, Jun

Fall 2024

Liang, Caroline

Parasites can indirectly impact hosts through non-consumptive effects (NCEs) via changes in behaviour, morphology, and/or physiology. These responses can be understood in terms of the ecology of fear framework. My study system involves a cactophilic fruit fly (Drosophila nigrospiracula) and a...

Spring 2019

Anderson-Baron, Matthew N

Organelles serve to compartmentalize biochemical functions within the eukaryotic cell. However, to collectively maintain cellular homeostasis, organelles must communicate in some way in order to coordinate these functions. Two such organelles,the peroxisome and the lipid droplet, are both...

Spring 2015

Parsons, Brendon D

The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...

Fall 2020

Fast, David

The digestive tract facilitates nutrient uptake in the presence of a heterogenous cohort of symbiotic microbes. These microbes along with their collective genetic material form the intestinal microbiome and contribute to animal phenotypes. Similar to mammals, the microbiome of insects forms a...

Spring 2013

Bond, David JE

The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...

Fall 2010

Deng, Hua

Vertebrate development requires the activity of multiple members of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation. Additionally, it is thought that several muscle-specific functions of MEF2 family proteins require binding additional...

Fall 2014

Strautman, Joel C

Hereditary Spastic Paraplegia (HSP) denotes a heterogeneous group of heritable neurodegenerative disorders predominantly characterized by progressive weakness and spasticity of the legs. Mutations in the gene SPAST are by far the most common, while mutations in the gene ATL1 are the second most...