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Skip to Search Results- 1Anderson, Warren G.
- 1Asomaning, Justice
- 1Brophy, Taylor Raymond
- 1Chu, Kevin
- 1Clifford, Alexander M
- 1Collins, Catherine Elizabeth Victoria
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Design and synthesis of renewable lipid-based nanocarriers with thermosensitivity for targeted drug delivery applications
DownloadSpring 2024
Numerous drug molecules currently available on the market suffer from short half-life, in vivo instability, poor bioavailability, rapid degradation and inappropriate distribution. While nanocarriers have emerged as a promising solution to address these issues, the primary objective and challenge...
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
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Growth of oleaginous yeasts on mixed C5 and C6 sugar streams to generate lipid feedstocks for renewable hydrocarbon production
DownloadSpring 2022
Microbial lipids are a promising feedstock to produce renewable fuels. Lignocellulosic feedstocks can provide multiple carbon sources for microbial growth, such as hexoses (C6) and pentoses (C5). Oleaginous yeasts can convert C5 and C6 sugars to microbial lipids that can be further processed into...