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- 2Sulfonylureas
- 1ATP-sensitive potassium channel
- 1Acute coronary syndrome
- 1Binding affinity
- 1Biophysics
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Spring 2012
Voltage-gated potassium (Kv) channels regulate the flow of potassium ions across the cell membrane of nerves and muscles. Proper functioning of these and other voltage-gated ion channels is critical for an animal to sense the environment and respond quickly to stimuli. Dysfunctional Kv channels,...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Building Evidence to Assess a Drug Safety Signal: the Association between Sulfonylureas and Adverse Cardiovascular Events
DownloadFall 2015
All drugs have the potential to cause adverse events that can result in hospitalization or death. In order to protect the public health, it is critical to employ methods to detect and assess adverse drug events in a timely manner. One of the most controversial and long standing drug safety issue...
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Fall 2018
Epilepsy is among the most common neurological diseases, but approximately 30% of epileptics are unresponsive to available drugs, and many more suffer significant side effects. One reason for the persisting large fraction of drug-resistant or drug-intolerant patients may be that most drug...
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Spring 2011
The cardiac sodium-calcium exchanger (NCX) is an important membrane protein which regulates cellular calcium necessary for the optimal contractile function of the heart. NCX has become a focal point in ischemic heart disease (IHD) research as evidence suggests that reactive oxygen species (ROS)...
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Spring 2019
Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and an insufficiency of insulin secretion from the pancreatic β cell. The incidence of T2DM is rising worldwide at an alarming rate. Increased prevalence of obesity is a major contributor to this rise in T2DM...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...