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- 5Wheeler, Michael B.
- 4Gänzle, Michael G.
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...
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Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammation
Download2013
Selinger, L. Brent, Inglis, G. Douglas, Uwiera, Richard R. E., Lone, Abdul, Xu, Yong
Background Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies...
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Carbon and Nitrogen Mineralization and Microbial Succession in Oil Sands Reclamation Soils Amended with Pyrogenic Carbon
Download2014-12-31
Mackenzie, M.D., Lanoil, B., Hofstetter, S., Hatam, I.
Land reclamation of oil sands disturbed boreal forests in Alberta is a challenging task facing companies with surface mine leases. The government requires reclamation to equivalent land capability, which is a vague statement at best. Agronomic theories and methodologies have been applied in the...
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Characterization of novel envelope proteins and their relationship with the Cpx response and stress resistance in Escherichia coli
DownloadFall 2022
Stress is a major factor every organism needs to mitigate to survive. Environmental factors such as oxygen content, temperature, and alkalinity can all induce stress and prevent life from progressing. For Escherichia coli and other members of the mammalian gastrointestinal tract they need to...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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2013-03-14
Sherman, Philip - Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes (INMD)
Dr. Philip Sherman (Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes [INMD]) outlined the 2009-2014 Strategic Priorities of INMD. These include Food and Health; Environments, Genes, & Chronic Disease; Obesity and Healthy Body Weight: Seeking Solutions; and Continuum of...
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Comparative genomics of Lactobacillus reuteri from sourdough reveals adaptation of an intestinal symbiont to food fermentations
Download2015
Zhao, Xin, Gänzle, Michael G., Lin, Xiaoxi B., Zheng, Jinshui
Lactobacillus reuteri is a dominant member of intestinal microbiota of vertebrates, and occurs in food fermentations. The stable presence of L. reuteri in sourdough provides the opportunity to study the adaptation of vertebrate symbionts to an extra-intestinal habitat. This study evaluated this...
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Fall 2012
Provided that infectious prions (PrPTSE) are inactivated, composting of specified risk material (SRM) may be a viable alternative to rendering and land filling. The overall objective of this research was to utilize laboratory-scale composters to assess the degradation of SRM and PrPTSE during...
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Content Validity of a Questionnaire Specifically Designed to Clinically Identify Pediatric Environmental Exposures
DownloadSpring 2014
Various clinical questionnaires exist to assist clinicians with the diagnosis, prognosis, long-term follow up of a disease, or even to assess quality of life. However, any questionnaire must be evaluated for its validity and reliability before application. Invalid or unreliable questionnaires can...