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Axon excitability testing shows increased IH activity in populations of slow versus fast motor axons of the rat
DownloadFall 2013
Despite extensive knowledge of variations in motoneuron (MN) soma and muscle properties across different healthy muscles or motor units, there is comparatively little knowledge about variations in motor axon electrophysiology across different axon groups. Axon excitability testing (AET) is an in...
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2015
Shrestha, S., Hogan, J.D., Ramesh, K.T. , Venkatesan, A., Fournier, A.J., Rajbhandari, L.
Although a number of cytoskeletal derangements have been described in the setting of traumatic axonal injury (TAI), little is known of early structural changes that may serve to initiate a cascade of further axonal degeneration. Recent work by the authors has examined conformational changes in...
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Retrograde signaling mechanisms of nerve growth factor regulating the survival and apoptosis of sympathetic neurons
DownloadFall 2009
The survival of several neuron populations during development, including sympathetic neurons, is strictly regulated by neurotrophins such as nerve growth factor (NGF) released from innervation targets. NGF activates its receptor, TrkA, at axon terminals, to generate signals that are transmitted...